Preventing Cushing: Iatrogenic Cushing Syndrome due to Ritonavir-Fluticasone Interaction
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چکیده
منابع مشابه
Preventing Cushing: Iatrogenic Cushing Syndrome due to Ritonavir-Fluticasone Interaction
Ritonavir is commonly used in low doses to boost plasma levels of protease inhibitors in patients with human immunodeficiency virus (HIV) infections. It is also a potent inhibitor of cytochrome P450. We present a 50-year-old African American male with past medical history of HIV on highly active antiretroviral therapy (HAART), which also included ritonavir and long standing asthma that has been...
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Summary A case of Cushing' s syndrome associated with application of topical clobetasol propionate (0.05%) is reported. Local application of clobetasol propionate is associated with adrenal suppression in normal subjects and on this basis, it has been recommended that less than 50 g per week be used. There have been sporadic case reports of cushing's syndrome associated with topical steroid bu...
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Ritonavir is a potent inhibitor of the cytochrome P450 enzyme CYP3A4 and is subject to multiple drug-drug interactions. This becomes especially important when the patient is also taking medications metabolized through CYP3A pathway as increased and potentially toxic drug levels may ensue. Herein we present one such interaction wherein a 57 year old gentleman with human immunodeficiency virus (H...
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HIV positive patients on ritonavir-containing antiretroviral therapy (ART) can develop iatrogenic Cushing syndrome (IACS) and adrenal insufficiency as a result of drug-drug interactions with inhaled or intranasal glucocorticoid therapy. Reports related to epidural triamcinolone injections are relatively uncommon but increasingly reported. We describe a 48-year-old woman with immunologically and...
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Paraneoplastic syndromes are rare disorders that are triggered by an altered immune system response to neoplasm. Paraneoplastic syndromes may be the first or the most prominent manifestations of cancer. Wilm's tumor is the most frequent pediatric renal malignancy and usually presents with abdominal mass. Unusual presentations like acquired von Willebrand disease, sudden death due to pulmonary e...
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ژورنال
عنوان ژورنال: Cureus
سال: 2017
ISSN: 2168-8184
DOI: 10.7759/cureus.1484